Cabeza Prieta National Wildlife Refuge is located to the north-west of Organ Pipe NM.

Buenos Aires National Wildlife Refuge is located south and east of Organ Pipe NM.

Just across the border, Mexico's Pinacate Reserve takes in the white sand dunes of the Gran Altar desert as well as a huge area of volcanic landscape.

Check out Arizona Borderlands for more information about the area surrounding Organ Pipe NM.