will need 4 weel drive car there? any motel/B&B place close to there?

My friends and I are planning a week-long backpacking trip in Smoky Mountain National Park in September 2012 and I wanted to know if anybody out there can recommend a 50 - 60 mile loop hike that would provide a backcountry campsite at the end of each day. If anybody out there can provide trail names and campsite information it would be very much appreciated! Thanks in advance.